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KMID : 0381920080380010043
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Korean Journal of Microscopy
2008 Volume.38 No. 1 p.43 ~ p.50
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Anticancer Effect of Ascorbic Acid and Saengshik on CT-26 Colon Cancer
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Kim Dong-Heui
Lee Kyu-Jae
Chang Byung-Soo
Yoon Yang-Suk
Teng Yung-Chien
Qi Xu-Feng
Kim Kwang-Yong
Lee Young-Mi
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Abstract
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Uncooked powered diet (Saengshik) composed of grains, vegetables, mushrooms and fruits have various physiological functions including strong antioxidant and potent anticancer effects by many kinds of bioactive phytochemicals. The objective of present study was to identify the anticancer effects of vitamin C and saengshik on colon cancer induced by CT-26 cell line in BALB/c mice. As the result, the tumor volumes of vitamin C-mixed diet group (VC) showed no significant differences compared with control group (C) after subcutaneous injection of CT-26 cell lines. However saengshik group (S) showed a significant effect, inhibiting the growth of cancer by 56.2% (), 48.1% (), 43.2% (), 55.5% (), 69.2% () and 70.7% () respectively as compared with C group at an interval of 5 days after injection of the CT-26 cells into mice. Also the final tumor volume of S group exerted a significant differences as compared with one of C group (p<0.05). Especially in the case of S group (n=10), the tumors in 2 of 10 mice entirely disappeared at 25th day. Our results suggest that saengshik possess a strong inhibitory action against tumor growth induced by CT-26 colon cancer cell line in the mice. Further studies of saengshik are required to confirm the cancer prevention effect and possibility of adjuvant cancer therapy.
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KEYWORD
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Saengshik, Effect, CT-26, Phytochemical, BALB/c
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